| 초록 |
The central strategy in regenerative medicine requires a biomaterial scaffold as a delivery carrier of cells and a depot to deliver bioactive molecules, which is eventually involved in regeneration processes of damaged tissue. Therefore, the ability of scaffolds to direct desirable cellular and tissue response is essential for the success of this approach. Although synthetic biodegradable materials have been widely used in regenerative medicine, they are mostly hydrophobic and showed limited interactions with cells and tissue. Therefore, many efforts have been made to render the surface properties of scaffolds to possess chemical and physical characteristics of native extracellular matrix (ECM). Recently, it has been reported that dopamine can be easily polymerized under slightly basic solution (pH 8.4) that is able to be deposited on the surface of materials regardless of their surface chemistry. In addition, the deposited polydopamine is useful to allow ad-layer formation of biomolecules containing thiol or primary amine groups through Michael or Schiff base reaction, which are stably adhesive under biological fluids. We used this simple process for the surface modification of biodegradable polymers and extensively studied its effect on in vitro cellular activities and in vivo tissue compatibility. One strategy includes electrospun nanofibers that were coated with polydopamine and inductive signals to guide bone regeneration. In this presentation, our approaches to develop cell-interactive scaffolds based on polydopamine-mediated surface modification for modulation of cell function will be discussed by providing several exemplary works in regenerative medicine. |
