| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
In Vitro Assessment of Antibacterial Properties and Cytotoxicity of Silver-containing PLGA Nanofibrous Scaffolds |
| 초록 |
Infections with bacteria have become a serious problem in joint arthroplasty. This study reports on in vitro antibacterial activity and in vitro cytotoxicity of PLGA nanofibers loaded with silver nanoparticles (520nm). In vitro antibacterial activity against Staphylococcus aureus and Klebsiella pneumoniae was studied by microplate proliferation tests. The adhesion, viability and proliferation properties of fibroblasts and osteoblasts were done to study in vitro cytotoxicity. Only silver-containing PLGA nanofibrous scaffolds showed high-antibacterial activity and an inhibitory effect on the growth of Staphylococcus aureus and Klebsiella pneumoniae. There was no significant difference regarding in vitro cytotoxicty between silver-containing and non-containing PLGA scaffolds. It was found, from in vitro experiments, that the silver-containing PLGA nanofibrous scaffolds have a potential to be used in joint arthroplasty. |
| 저자 |
싱즐챠이, 백진영, 채원표, 강인규
|
| 소속 |
경북대 |
| 키워드 |
Antibacterial; Cytotoxicity; Nanofiber
|
| E-Mail |
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