| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Biomimetic modification of mechanically expanded fibrous meshes for vascular tissue engineering using gamma-ray irradiation |
| 초록 |
In vascular tissue engineering, there are many approaches to mimic the natural composition of the blood vessel containing intima, media, and adventitia layers. As one of those approaches, we developed blend nanofibrous meshes using electrospinning, and mechanically expanded the meshes. To increase the bioactivity of the meshes, we introduced carboxyl group, and gelatin was conjugated on them. Introduction of carboxyl group was regulated by polymer blending ration at constant AAc concentration and irradiation dose, gelatin was successfully immobilized. In smooth muscle cell (SMC) experiment, initial viability of the SMC was increased on the gelatin functionalized meshes, and SMC infiltration and proliferation were also significantly increased on them. Therefore, our gelatin-functionalized and mechanically expanded meshes may be a good candidate to be essential layer in blood vessel. |
| 저자 |
신영민1, 임윤묵1, 정진오1, 임종영1, 최종배1, 권희정1, 박종석1, 정성린1, 윤세미2, 서다은2
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| 소속 |
1한국원자력(연), 2충남대 |
| 키워드 |
biomimetic modiciation; gamma-ray irradiation
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| E-Mail |
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