| 초록 |
Optically active chloromethyloxirane was obtained from 1,3-Dichloro-2-propanol by a process of asymmetric synthesis. The highest enantiomeric excess (EE%) and conversion obtained were 100% within 2hrs, using Rs-tech and K3PO4H2O as the catalyst and base. For the purpose of comparison, A series of parallel experiments have been done, using different bases, solvents,different ratios of the reactant,base and catalyst .A variety of cobalt(salen) type complexes were also prepared to compare with the Rs-tech catalyst. Optically active chloromethyloxirane was obtained according to kinetic resolution mechanisms.These catalysts showed a high enantioselectivity and activity for this Ring-closing reaction. |
