| 초록 |
Cetirizine dihydrochloride (CTZ) is a selective histamine (H1)-receptor antagonist that is indicated for the relief of symptoms associated with seasonal and perennial allergic rhinitis. In this work, cetirizine dihydrochloride was recrystallized by the SAS (supercritical antisolvent) process at various temperature andpressure conditions. The drug compound was dissolved in various organic solvents, such as ethanol, methanol, DMF and DMSO.As a antisolvent, supercritical carbon dioxide (sc-CO2)hasbeen used for the purpose of micronizationof cetirizine dihydrochloride.The thermal behavior of the recrystallized particles were investigated using differential scanning calorimetry (DSC). The physicochemical properties of the different products were characterized by Fourier transform infrared spectroscopy (FT-IR) and powder X-ray diffractometry (PXRD), andField Emission scanning electron microscopy (FE-SEM). |
