| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis and Characterization of Novel Thermosensitive and Biodegradable Pluronic F127 Derivatives for Cartilage Tissue Engineering |
| 초록 |
Thermogelling Pluronic F127 was approved by FDA as a material for a living body, and it has been studied extensively as a biocompatible material for drug delivery system and tissue engineering. In this study, we synthesized novel temperature-sensitive and biodegradable Gly-Arg-Gly-Asp (GRGD) peptide was grafted Pluronic F127 derivatives. These polymers were characterized by 1H-NMR, FTIR, GPC, and elemental analyzer. The sol-gel transition temperature was determined by the test tube inverting method and dynamic mechanical analysis. At 20 wt%, the sol-to-gel transition temperature of FGM-RGD aqueous solution was similar with F127. The cytotoxicities of these polymers were evaluated in relative cell viability of chondrocytes using WST-8 assay. |
| 저자 |
최보규1, 박귀덕1, 안광덕1, 정병문2, 한동근1
|
| 소속 |
1한국과학기술(연), 2이화여자대 |
| 키워드 |
Tissue Engineering; Thermosensitivity; Pluronic F127 derivatives; RGD; chondrocytes
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| E-Mail |
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