| 학회 | 한국화학공학회 |
| 학술대회 | 2001년 가을 (10/19 ~ 10/20, 한밭대학교) |
| 권호 | 7권 2호, p.2933 |
| 발표분야 | 공정시스템 |
| 제목 | 단백질 접힘과 전체 최적화 |
| 초록 | Computation of protein structure is one of the challenges of contemporary biology. A fundamental approach to this problem, using first principles, is based on the thermodynamic hypothesis formulated by Anfinsen [1]. The three-dimensional structure of a native protein in its physiological environment is the one in which the free energy of the whole system is lowest. Successful protein structure computation with this approach entails two separate and very difficult problems: deriving a reliable potential energy function and developing an efficient optimization method for conformational search. Although the thermodynamic approach [2] is base on sound physical grounds, it has not been as successful as other approaches such as sequence-homology and threading methods. Two main obstacles are the insufficient quality of available force fileds and the multiple minima problem. Protein structure prediction based solely on the thermodynamic hypothesis has heretofore been considered to be infeasible [3]. In this report we present a novel approach for protein structure computation based on global optimization of a potential energy function, and demonstrate its feasibility in blind tests on CASP3 experiments [4]. |
| 저자 | 이주영 |
| 소속 | 고등과학원 |
| 키워드 | 단백질 접힘 |
| VOD | VOD 보기 |
| 원문파일 | 초록 보기 |
