| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
A Synthetic Polyampholyte for Supramolecular Complexation of Paclitaxel |
| 초록 |
Paclitaxel is one of the important and effective anticancer drugs for the treatment of various types of cancers. Due to the hydrophobicity and insolubility of paclitaxel in water, chemophores and ethanol with a potential of cytotoxicity have been used in the current formulation for the intravenous administration. In order to overcome these problems, a synthetic polyampholyte was synthesized as macromolecular carrier using the supramolacular concept. It was found that the formulated complexes of paclitaxel and the polyampholyte showed a higher water-solubility and a stronger anticancer effect on two cancer cell lines such as the human breast cancer and human lung cancer cell line compared to the pristine paclitaxel. |
| 저자 |
이연주1, Kurt E. Geckeler2
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| 소속 |
1광주과학기술원 신소재공학과, 2광주과학기술원 나노바이오전자재료공학과 (WCU) |
| 키워드 |
Paclitaxel; Polyampholyste; Anticancer
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| E-Mail |
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