화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터)
권호 36권 1호
발표분야 기능성 고분자
제목 Viability, Cellular Uptake and Immune Response of Silica-Titania Hollow Nanoparticles as a function of size and surface functionality
초록 Silica-titania hollow nanoparticles (HNPs) with uniform sizes of 25, 50, 75, 100, and 125nm were prepared by dissolution and redeposition method. Surface-functionalized HNPs with cationic, anionic, and neutral functional group were obtained by silane treatment. The cellular uptake, cytotoxicity, and immune response of HNPs of different sizes and surface functionalities are investigated toward human breast cancer and mouse alveolar macrophage cells. The HNPs represents size- and surface functionality-dependent uptake and toxicity.
저자 장정식1, 오완규2, 김소진3, 정윤선1
소속 1서울대, 2화학생물공학부, 3화학생물공학부 에너지환경 화학융합기술 전공 (WCU)
키워드 cytotosicity; cellular uptake; immune response; hollow nanoparticles; surface funtional group; size dependence
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