| 초록 |
Cephalosporin C is a beta-lactam antibiotic synthesized as a secondary metabolite by strains of a strictly aerobic fungus Cephalosporium acremonium. This natural antibiotic is modified through chemical or enzymatic methods to produce different semi-synthetic cephalosporins, which are of major importance in the pharmaceutical market. In this work, a mathematical model of cybernetic viewpoints has been developed to describe the fermentation process of C. acremonium. The proposed model, which takes into account the diauxic behavior of substrate consumption and the morphological differentiation simultaneously, has been tested on the experimental data from the literatures. The results obtained show that the model can adequately describe the morphological differentiation of cells, the sequential utilization of carbon sources and the production of cephalosporin C, so it should be useful to optimize the production process of cephalosporin C by C. acremonium in batch or continuous operations. |
