| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
International Symposium on Theranostic Macromolecules(의료용 고분자 부문위원회) |
| 제목 |
Layer-by-Layer Assemblies of Polymers and Proteins Using Weak Interaction and Their Biomedical Applications |
| 초록 |
The design and control of substrate surfaces with nanometer- or micrometer-sized polymer films are of considerable interest for both fundamental and applied studies in the biomedical field because of the required surface properties. The layer-by-layer (LbL) technique was discovered in 1991 by Decher and co-workers for the fabrication of polymer multilayers constructed mainly through electrostatic interaction. We have extended the scope and applicability of this LbL assembly by introducing molecularly regular conformations of polymers or proteins by employing for the first time weak interactions, such as der Waals interactionsand biological recognition. Since these weak interactions are the sum of the attractive or repulsive forces between parts of the same molecule, they allow macromolecules to be easily arranged into the most stable conformation in LbL film. It is the first time achievement ofstereocomplexLbL formations of stereoregular polymers and their application for stereospecific template polymerization and nanomaterials using methacrylic acid (MAA) and methyl methacrylate (MAA). We have also reported for the first time extracellular matrix (ECM) multilayers focused on fibronectin (FN) using biologically specific recognition. By using the ECM multilayers, three-dimensional (3D) cellular multilayers could be developed to apply for tissue engineering and pharmaceutical application. |
| 저자 |
Mitsuru Akashi |
| 소속 |
Department of Applied Chemistry |
| 키워드 |
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| E-Mail |
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