| 학회 |
한국화학공학회 |
| 학술대회 |
2014년 가을 (10/22 ~ 10/24, 대전 DCC) |
| 권호 |
20권 2호, p.1553 |
| 발표분야 |
생물화공 |
| 제목 |
Microbial production of 2-hydroxyacid containing polyhydroxyalkanoates using metabolically engineered Ralstonia eutropha |
| 초록 |
Microbial production of 2-hydroxyacid containing polyhydroxyalkanoates using metabolically engineered Ralstonia eutrophaPHAs consisting of 2-hydroxyacids as monomer units have attracted much attention, but their production has not been efficient. Here, we report the metabolic engineering strategies for the development of recombinant Ralstonia eutropha strains to synthesize PHAs containing 2-hydroxyacids as monomers. This could be achieved by the construction of base R. eutropha strains that express engineered PHA synthase able to use 2-hydroxyacyl-CoAs (2HA-CoAs) as substrates and engineered propionyl-CoA transferase to synthesize 2HA-CoAs. [This work was supported by the Technology Development Program to Solve Climate Changes (Systems Metabolic Engineering for Biorefineries) from the Ministry of Science, ICT and Future Planning (MSIP) through the National Research Foundation (NRF) of Korea(NRF-2012-C1AAA001-2012M1A2A2026556)] |
| 저자 |
양정은1, 박시재2, 이승환3, 이상엽1
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| 소속 |
1한국과학기술원, 2명지대, 3한국화학(연) |
| 키워드 |
Polyhydroxyalkanoate; Metabolic engineering
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| E-Mail |
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| 원문파일 |
초록 보기 |
