| 초록 |
Magnetic poly ε-caprolactone (PCL) nanoparticles were prepared in a well shaped spherical form with a size range of 150 ~ 340 nm by the emulsion method. The influence of some preparative variables on the size and surface property, such as the internal/external phase ratio, external stabilizer concentration was investigated. Nanoparticles prepared by emulsion were smooth, well individualized and homogeneous in size. The presence of magnetite and its superparamagnetic characteristic were confirmed by FT-IR spectra and VSM, respectively. We find that the amount of DOX encapsulated in the magnetic nanoparticle prepared by emulsion method. The drug release characteristic was dependent on the synthetic methods. By emulsion method, a typical release behavior was observed where a large fraction of encapsulated drugs was released as an initial rapid in the first 3 days followed by a slight release step for 5 ~ 30 days. In-vitro experiment of magnetic susceptibility under external magnetic field demonstrated that the magnetic PCL nanoparticles have sufficient magnetic susceptibility for a potential magnetic drug carrier for targeted delivery. |
