| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Tumor vasculature targeting using thiol-reactive PEG-PLLA micelles |
| 초록 |
The functionalization of polymeric micelles with tumor-homing peptides enables them to achieve the enhanced therapeutic efficacy against tumors. Herein, vinylsulfone-terminated PEG-PLLA (VS-PEG-PLLA) was synthesized as a thiol-reactive amphiphilic block copolymer and VS-PEG-PLLA micelles revealed the size around 35 nm with a spherical shape. The reactivity of micelles toward thiol-contained targeting ligands (CREKA and cRGDfC) was evaluated by monitoring thiol concentration with Ellman’s method. For tumor vasculature targeting, single or dual ligands-tethered PEG-PLLA micelles were prepared and their in vivo targetability was investigated by optical imaging. |
| 저자 |
배진우, 박경민, 이유진, 박기동
|
| 소속 |
아주대 |
| 키워드 |
Polymeric micelle; tumor targeting; peptides; imaging
|
| E-Mail |
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