| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.642 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Composite of SIS Sheet and Poly(n-vinylpyrrolidone) for Wound Dressing |
| 초록 | Tissue engineering techniques have been investigated the possibility of the application of small intestine submucosa (SIS) for a wound dressing. SIS is the natural biomaterials mainly composed of collagen, glycosaminoglycan and growth factors1. It has been recently recognized that SIS has been examined as organ reconstructions without immuno-rejection response2. We attempted that the synthetic polymer was used to compose the wound dressing with SIS sheet. The aqueous solution of poly(n-vinylpyrrolidone) (PVP) 10 wt%, 20 wt% and 30 wt% were prepared and native SIS sheet immersed into the solution and then lyophilized. Morphologic observation of the composite was characterized by scanning electron microscopy (SEM) and water uptake ability was examined to evaluate the possibility as wound dressing. Also, the enzymatic degradation test was carried out to observe the effect of PVP and compared with native SIS sheet. The SIS-PVP composite showed lower enzymatic degradation than native SIS sheet. In conclusion, we suggest that SIS-PVP composite can be used as a wound healing and tissue construction. Acknowledgement : This work was supported by Korea Ministry of Commerce, Industry and Energy (N11-A08-1402-05-1-3). Fig. 1. Water uptake ability of various sheets. Fig. 2. SIS-PVP 10 wt% composite sheet surface. Reference 1. S. B. Song, G. Khang, S. W. Hong, I. W. Lee, S. W. Kim and H. B. Lee, Biomaterials Research, 4, 13 (2000). 2. K. Lindberg, and S. F. Badylak, Burns, 27, 254 (2001). |
| 저자 | 홍금덕1, 김선화1, 신혜원1, 강길선1, 김문석2, 조선행2, 이해방2 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | Wound dressing; PVP; SIS sheet |
