| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Fatty Acid-based Thermosenstive Fiber for Temperature-Regulated Drug Release |
| 초록 |
This paper describes fatty acid-based thermosensitive fibers for temperature-regulated drug release. The fibers have core-sheath structure. Rhodamine B-loaded polymer particles are confined in the core while the sheath contains biodegradable polymer and mixture of fatty acids. The mixture consists of two fatty acids with different melting points. At a specific composition, the mixture represents a single melting point of 38-40 oC which is slightly above the normal human body temperature. This controllable melting of the mixture allows the temperature-regulated release of the dye from the fibers. Below its melting point, the mixture of fatty acids incorporated into the sheath will be in a solid state to restrict the passing of the dye molecules pre-loaded in the core whereas the molecules can be released instantly through the pores over the melting point. The release profiles of the dye molecules can be further manipulated by varying the amount of the mixture contained in the fibers. |
| 저자 |
박주향1, 오현진1, 황세정1, 현동춘1, 강동국2
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| 소속 |
1경북대, 2(주) 평화오일 씰 |
| 키워드 |
fatty acid; Poly(ε-capolactone); temperature-controlled release; drug delivery; electrospinning
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| E-Mail |
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