| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Preparation and evaluation of Paclitaxel (PTx) loaded MPEG-PLGC films for drug carrier. |
| 초록 |
In drug delivery field, carrier design is a critical point. Because, The drug release period can be varied from weeks to months, depending on the molecular weight and chemical composition of the biodegradable polymer segments. Polylactide (PLA), poly(e-caprolactone) (PCL) and poly(lactide-co-glycolide) (PLGA) are good drug delivery carriers and approved by FDA. However, because of the copolymer was semi-crystallization, low biodegradation rate and poor flexible property. In the present work, we synthesised random copolymers MPEG-b-(PLLA-ran-PGA-ran-PCL) (MPEG-PLGC) witch is different compositions and types of monomer units give a range of materials with different mechanical and biodegradation properties. Then, Anti-cancer drug PTx (Paclitaxel) loaded in MPEG-PLGC. Also, evaluated that the polymers provoke an in vivo inflammatory response. Thus, MPEG-PLGC diblock copolymer can act as drug delivery carrier with biodegradation materials from a few weeks to a few months. |
| 저자 |
박지훈, 권두연, 이보근, 이건희, 김재호, 김문석
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| 소속 |
아주대 |
| 키워드 |
drug carrier; biodegradable polymer; aliphatic polyester
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| E-Mail |
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