| 학회 |
한국고분자학회 |
| 학술대회 |
2002년 봄 (04/12 ~ 04/13, 서울대학교) |
| 권호 |
27권 1호, p.37 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Glycol-Chitosan Nanoaggregates for Tumor Targeting Drug Delivery System Using EPR Effect |
| 초록 |
A polymer-drug conjugate having acid-sensitive spacer was synthesized. And it formed micelle-like self-aggregates. This was designed to take some advantages of macromolecular prodrugs and polymeric carriers like micelles, and to release antitumor agents in the acidic environment of tumor tissues. Adriamycin, an anthracycline antitumor agent, was covalently conjugated to glycol chitosan through the introduction of acid-sensitive cis-aconityl spacer. The adriamycin-conjugated glycol chitosan with both hydrophilic groups (ethylene glycol and hydroxyl groups) and hydrophobic groups (anthracycline groups) formed spontaneously micelle-like self-aggregates in aqueous media. The self-aggregates had a narrow and unimodal size distribution, and its hydrodynamic diameter measured by dynamic light scattering was 220 ~ 280 nm. The spherical shape of the self-aggregates was visually confirmed by atomic force microscopy. The conjugate exhibited pH-sensitive release behavior induced by acid labile cis-aconityl spacer. Glycol-chitosan self-aggregates should accumulate passively to the tumor tissue due to the enhanced permeability and retention (EPR) effect. The self-aggregates of the adriamycin-glycol chitosan conjugate may be useful not only as a macromolecular prodrug for passive tumor targeting but also as a long circulating vehicle. |
| 저자 |
손연주1, 조용우2, 정혜선3, 정서영4, 박종래*, 김인산**, 서상봉***, 권익찬
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| 소속 |
1KIST 의과학센터, 2*서울대, 3**경북대, 4***(주) 자광 |
| 키워드 |
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| E-Mail |
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| VOD |
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