| 초록 |
Our work introduced a water-insoluble amphiphilic block copolymer, methoxy poly(ethylene glycol)-b-poly(ɛ-caprolactone) (mPEG-b-PCLL), to stabilize nanoemulsions through the formation of a semi-solid interphase at the O/W interface. We found out that the amphiphilic block copolymer could stabilize nanoemulsions of hydrocarbon oils with a new hydrophobic block comprising L-lactide and ɛ-caprolactone which can reduce the crystallinity of the block. The prepared nanoemulsions were successfully dispersed in water at room temperature, reorganizing semi-solid polymeric barrier at O/W interface even under a high level of external stresses (e.g., pH, ionic strength, and temperature). This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HN12C0064). |
