| 학회 |
한국화학공학회 |
| 학술대회 |
2005년 가을 (10/21 ~ 10/22, 인하대학교) |
| 권호 |
11권 2호, p.1632 |
| 발표분야 |
고분자 |
| 제목 |
Synthesis of High-Molecular-Weight Poly(L-Lactic acid)-Based Copolymers via in situ Direct Condensation Polymerization |
| 초록 |
Poly(L-lactic acid-co-succinic acid-co-1,4-butanediol)(PLASB) was synthesized by a direct condensation copolymerization in bulk state using titanium(Ⅳ) butoxide(TNBT) as a catalyst. Weight average molecular weight(Mw) of PLASB increased from 3.5×104 to 2.1×105 as the content of SA and BD went up from 0.01 to 0.5 mole/100 mole of L-lactic acid(LA). PLASB having Mw in the range from 1.8×105 to 2.1×105 showed tensile properties comparable to those of commercially available poly(L-lactic acid)(PLLA). In sharp contrast, homopolymerization of LA in bulk state produced PLLA with Mw as low as 4.1×104, and it was too brittle to prepare specimens for the tensile tests. PLASB synthesized by using various catalyst. Ethylene glycol oligomers with different chain length were added to LA/SA in place of BD to investigate effect of chain length of ethylene glycol oligomers on the Mw of the resulting copolymers. Biodegradability of PLASB was analyzed by using the modified Sturm test. Toxicity of PLASB was evaluated by counting viable cell number of mouse fibroblast cells which had been in contact with PLASB discs. |
| 저자 |
김훈식1, 양혜선2, 김말남2, 윤진산1
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| 소속 |
1인하대, 2상명대 |
| 키워드 |
PLA; Synthesis; copolymer
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| E-Mail |
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| 원문파일 |
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