| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 가을 (10/11 ~ 10/12, 군산대학교) |
| 권호 | 27권 2호, p.182 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Study on in vitro release patterns of fentanyl-loaded PLGA microspheres |
| 초록 | In order to the development of the delivery device of long-acting local anesthetics for postoperative analgesia and control of chronic pain of cancer patient, fentanyl loaded poly(L-lactide-co-glycolide) (PLGA, molecular weight; 5,000, 8,000, 20,000, and 33,000 g/mole) microspheres (FMS) were studied. FMS were prepared by an emulsion solvent-evaporation method. The influence of several preparation parameters such as initial drug loading, PLGA concentrations, emulsifier concentrations, oil phase volume, and mole ratio and molecular weight has been investigated on the fentanyl release patterns. Generally, the drug showed the biphasic release patterns, with an initial diffusion followed by a lag period before the onset of the degradation phase, but there were no lag time in our device. Fentanyl was slowly released from FMS over 10 days in vitro with a quasi-zero order property. The release rate increased with increasing drug loading as well as increasing polymer concentration with relatively small initial burst effect. From the results, FMS may be a good formulation to deliver the anesthesia for the treatment of chronic pain. Acknowledgment: This work was supported by KMOHW (Grant No.; HMP-98-G-2-050-A). |
| 저자 | 서선아1, 강길선2, 이종문, 이해방* |
| 소속 | 1전북대, 2*한국화학(연) |
| 키워드 | fentanyl; microsphere; PLGA; release pattern |
