| 초록 |
For progression and metastasis of breast cancer, the interaction between the transmembrane receptor CD44 and its ligand hyaluroic acid (HA) matrix has important.[1] In especial, the molecular weight of HA can be a key point for targeting toward CD44-high expressed cancer cells and their metabolism. For this purpose, high molecular weight of hyaluronic acid was chopped off using hyaluronidase to produce various low molecular weight of HA. For evaluation of targeting efficacy, subsequently, various molecular weight of HA was conjugated with MnFe2O4 nanocrystals (MNCs) as MR imaging contrast agents. Herein, hydrophobic MNCs surface was then modified with amphiphilic poly (vinyl alcohol) allowing MNCs to transfer from the organic to the aqueous phase. Water-dispersible MNCs (WMNCs) were further coated with HA for inducing the targeting ability toward CD44-high expressed cancer cells. To access the targeting efficiency of the synthesized various molecular weight of HA coated MNCs (HMNCs). |
