| 초록 |
Reactive oxygen species (ROS) are a group of highly reactive small molecules generated by all aerobic organisms and play essential roles in living organisms. The overproduction of ROS causes oxidative stress, resulting in significant damages to cell structures such as DNA and proteins. In particular, hydrogen peroxide (H2O2) plays a key role as a second messenger in cellular signaling, but its overexpression leads to oxidative damages to tissues and organs and has been implicated in inflammatory responses and various life-threatening diseases. However, various chemotherapeutic agents induce the production of H2O2 which causes apoptotic cancer cell death. Therefore, H2O2 has great potential as a diagnostic and therapeutic biomarker of inflammatory diseases and cancer. This presentation will discuss the rational design of novel oxidative stress regulating biomaterials and therapeutic efficacy in the studies of cell culture models and mouse models. |
