| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Antioxidant copolyoxalate prodrug nanoparticles for the treatment of inflammatory diseases |
| 초록 |
We developed fully biodegradable vanillyl alcohol-incorporated copolyoxalate (PVAX) that covalently incorporates vanillyl alcohol and peroxalate linkages in its backbone. PVAX was designed to react with H2O2 and hydrolytically degrade, leading to H2O2 scavenging and release of therapeutic vanillyl alcohol. PVAX was formulated into nanoparticles which had a mean size ~550nm in diameter. The polymer nanoparticles are able to image H2O2 and serve as therapeutic agents with potent antioxidant activity. The in vivo studies using a Hindlimb ischemia/reperfusion model showed that PVAX nanoparticels exerted antioxidant and anti-inflammatory activities by reducing the recruitment of eosinophils. Furthermore, PVAX nanoparticles are capable of imaging H2O2 in vivo with excellent specificity over other ROS. PVAX-based chemiluminesent and antioxidant nanoparticles have great potential as a theranostic agent for H2O2-associated inflammatory diseases. |
| 저자 |
임형석, 김형민, 김지혜, 고은별, 정다희, 강길선, 이동원
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| 소속 |
전북대 |
| 키워드 |
Nanoparticles; Antioxidant; Chemiluminesent
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| E-Mail |
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