| 초록 |
The mechanisms underlying the tumor targeting with self-assembled nanoparticles were investigated in terms of the physicochemical properties of nanoparticles and tumor microenvironments. Self-assembled nanoparticles were preferentially localized in perivascular regions, implying their extravasation to tumors through the hyperpermeable tumor vasculature. The magnitude and pattern of tumoral distribution of self-assembled nanoparticles were influenced by several key factors - i) in vivo colloidal stability: nanoparticles should maintain their intact nanostructures in vivo for a long period of time, ii) particle size, iii) intracellular uptake of nanoparticle: fast cellular uptake greatly facilitates the tumor targeting, iv) tumor angiogenesis: pathological angiogenesis permits access of nanoparticles to tumors. This work can provide insight for the engineering of nanoparticles and be extended to cancer therapy and diagnosis. |
