| 학회 | 한국공업화학회 |
| 학술대회 | 2012년 가을 (10/31 ~ 11/02, 대전컨벤션센터) |
| 권호 | 16권 2호 |
| 발표분야 | 포스터-생물공학 |
| 제목 | Synthesis and anti-melanogenic activity of small molecule-peptide conjugates |
| 초록 | Small molecule conjugated peptides were prepared by solid-phase synthesis as potential novel whitening agents, and their melanogenesis inhibitory activities were investigated. The conjugated small molecules having tyrosinase inhibitory activity were selected using mushroom tyrosinase assay. Through this method, caffeic acid and p-coumaric acid were screened. And, peptides having MC1R antagonist activity was designed by sequences originated from alpha-melanocyte stimulating hormone(α-MSH) or agouti signaling protein(ASP). Anti-melanogenic activities of small molecule-peptide conjugates were performed by melanin inhibitory assay using B16F1 melanoma cell line. Acknowledgement This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry of Health & Welfare, Republic of Korea.(Grant No. : A103017) |
| 저자 | 이혜숙, 신경훈, 류근석, 지경엽, 조인식, 김한영 |
| 소속 | 애경산업 |
| 키워드 | Peptide; Tyrosinase; Anti-melanogenic activity |
