| 학회 | 한국공업화학회 |
| 학술대회 | 2013년 봄 (05/01 ~ 05/03, ICC JEJU) |
| 권호 | 17권 1호 |
| 발표분야 | 포스터-생물공학 |
| 제목 | Effect of iron chelators on photodynamic therapy efficiency in tumor cells |
| 초록 | The effect of iron chelator on the production of protoporphyrin IX (PpIX) and photodynamic therapy was investigated in tumor cells. PpIX generation was successfully increased as addition of iron chelators with 5-aminolevulinic acid (ALA) or methyl amino levulinic acid (MALA). The presence of iron chelators could induce increased phototoxicity and higher PpIX accumulation into the tumor cells than did ALA or MALA alone. Furthermore, iron chelators with ALA or MALA accelerated apoptosis/necrosis of tumor cells, compared to ALA or MALA alone. Acknowledgment: This study was supported by a grant of the Korean Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (Project No. A091047). |
| 저자 | 정정욱, 정영일, 김시현, 이혜명, 강대환 |
| 소속 | 양산부산대 |
| 키워드 | iron-chelator; photodynamic therapy |
