| 학회 |
한국화학공학회 |
| 학술대회 |
2009년 봄 (04/23 ~ 04/24, 광주 김대중컨벤션센터) |
| 권호 |
15권 1호, p.878 |
| 발표분야 |
재료 |
| 제목 |
Microfluidics-assisted synthesis of submicron-sized heparinazed hydrogel |
| 초록 |
Over the past decades, considerable interest has been shown in the fabrication of polymeric gels at the nano-to-micrometer scale. Nanogel especially offer significant advantages for drug delivery because oftheir nanoscale size and high stability compare to conventional microgel. Microfluidic flow-focusing devices made of PDMS provide a versatile approach to prepare monodisperse drops at a high frequency. However, they have significant drawbacks as the size of channel decrease: leaking can occur at the interface between PDMS and glass due to the high flow rates and pressure, and continuous-flow microfluidics tend to undergo chaotic oscillations in which flows vary uncontrollably. In this work, we overcame these problems by optimizing the design of microfluidic channel. The flow-focusing microfluidic devices were used to generate submicron sized emulsion droplets as a template for fabrication of nanogel. Biodegradable heparin was used as model polymeric materials due to the distinctive properties of heparin. Photo-crosslinkerable heparin was prepared by substituting the carboxylic groups of heparin with acrylate groups. Aqueous emulsion droplets of heparin were crosslinked by UV light in the microfluidic device. |
| 저자 |
정웅찬, 최재훈, 임종민, 양승만
|
| 소속 |
한국과학기술원 생명화학공학과 / 광자유체집적소자연구단 |
| 키워드 |
Microfluidics; hydrogel; durg delivery; droplets
|
| E-Mail |
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| 원문파일 |
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