| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
고분자 구조 및 물성 |
| 제목 |
Insertion Mechanism of Peptide Molecules intoPhospholipid Bilayers ; X-ray and Neutron reflection studies |
| 초록 |
Structures of Lipid bilayers in a buffered solution as a model biological cell membrane are investigated using synchrotron X-ray and neutron reflectivity technique, in order to visualize the binding and penetration mechanism of trans-acting activator of transduction peptides, which were known as a protein transduction domain of human immunodeficienty virus into the those lipid membranes. At a photon energies of 21 keV, X-ray reflection could sucessfully reveal the detailed bilayered structures through a buffer solution, in a nanometer scale. Furthermore, neutron reflectivity was also used to detect the water distribution near the bilayer, and we could successfully obtain the structure of pores formed by the highly accumulated peptide molecules in the bilayer during the binding-insertion process. |
| 저자 |
신관우1, 최동진1, 유청종2, 이동렬2, 김만원3, 문준혁3, 홍대현1
|
| 소속 |
1서강대, 2포항가속기(연), 3KAIST |
| 키워드 |
Neutron Scattering; X-ray Scattering; Phospholipids
|
| E-Mail |
|
