| 초록 |
Surface enhanced Raman scattering (SERS) has extensive applications in biological sciences because of its unique characteristics such as high sensitivity, lack of photobleaching, and excitation of multiple Raman dyes by a single laser. We have developed a new class of SERS substrates for highly sensitive detection of biological molecules. Raman dye-induced, silver nanoparticle aggregates were encapsulated in the polymeric nanofibers via electrospinning and these nanofibers were chemically crosslinked by UV irradiation. The SERS substrates have controlled SERS intensity by introduction of different amounts of clustered silver nanoparticles in the nanofibers while maintaining biocompatibility and chemical stability in the wide range of pH and ionic strength. Controllable SERS signal, high sensitivity, stability against severe chemical environments, biocompatibility as well as large-scale synthesis at low cost make the electrospun SERS substrates useful for biosensing applications. |
