| 초록 |
Heparin, highly sulfated polysaccharide belonging to the family of glycosaminoglycan (GAG), is known to have multiple anticancer mechanisms, including inhibition of tumor angiogenesis, interference with tumor cell adhesion, and suppression of tumor cell invasion. In this study, a polymeric particulate drug delivery system was designed by using heparins as the hydrophilic backbone for its anti-tumor activities. The drug-loaded hydrophobic part was conjugated on the side chain of heparins. In addition, the heparin-based drug carriers were designed by importing ligands on the hydrophilic backbone to achieve active tumor targeting for effective cancer treatment. |
