| 초록 |
In this study, we report a simple and commercially tangible approach for the synthesis of PL end-capped poly(urea acetal)s for use as a drug carrier. These hybrid materials were synthesized via a condensation of 3,9-bis(3-aminopropyl)-2,4,8,10-tetraoxaspiro[5.5]-undecane and isophorone diisocyanate and end-capped with phospholipids such as soybean lecithin-based L-α-phosphatidylethanolamine and 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphoethanol-amine. The acid-degradable nature of the material was confirmed by nuclear magnetic resonance spectroscopy and dynamic light scattering. Moreover, in vitro and in vivo studies of drug loading and delivery efficiencies, cellular uptake behavior, cytotoxicity, and antitumor efficacy were also performed to understand the further insights of PL end-capped poly(urea acetal)s in anticancer therapy. |
