| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Osteogenic Differentiation of Bone Marrow Stem Cells using Thermo-Sensitive Hydrogels |
| 초록 | Poly(ethyleneglycol)-based diblock and triblock thermo-sensitive polyester copolymers were investigated for the application of tissue engineering and injectable biomaterials in drug delivery system due to their nontoxicity, biocompatibility and biodegradability. We synthesized the diblock copolymers consisting of methoxy poly(ethyleneglycol) (MPEG) (Mn=750 g/mole) and poly(ε-caprolactone) (PCL) by ring opening polymerization of ε-CL with MPEG as an initiator in the presence of HCl․Et2O. The effect of diblock copolymers on in vivo osteogenic differentiation of rat bone marrow stromal cells (BMSCs) with and without the presence of osteogenic supplements (dexamethasone) was investigated. Thin sections were cut from paraffin embedded tissues and histological sections were stained by H&E, von Kossa, and immunohistochemical staining for osteocalcin. In conclusion, dexamethasone containing thermo-sensitive hydrogel might be improved osteogenic differentiation of BMSCs. We expect the osteoinduction effect will be excellent when it used stem cell or other osteogenic materials Acknowledgement : This study was supported by KMOICE (0405-BO01-0204-0006) and SC3100 |
| 저자 | 김선경1, 현훈1, 김순희1, 김문석2, 이해방2, 강길선1 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | hydrogels; osteogenic differentiation |
