| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.661 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Design of Biodegradable Porous Membrane Morphology using Immersion Precipitation Method |
| 초록 | There are many applications of biodegradable membrane such as scaffolds, guided bone regeneration, wounded dressing and tissue adhesion barrier for tissue engineering and controlled drug release for drug delivery system. In applications of biodegradable membrane, the pore size and structure of membrane are very important factor. In our study, we prepared membrane by immersion precipitation method. And we control the pore size and structure of membrane with different variables(concentration of polymer; viscosity of polymer by mixing two kinds of PLGA which has different molecular weight; concentration of solvent; kind of solvent and non-solvent). We investigated that these variables have an effect on the structure of membrane. And we observed the relations between the pore size of membrane and the drug release profile using membrane loaded tetracycline as a model drug. Membrane structure was observed by scanning electron microscophy (SEM) and drug release profile was obtained by high-performance liquid chromatography(HPLC). |
| 저자 | 손서연, 한승훈, 김중현 |
| 소속 | 연세대 |
| 키워드 | biodegradable; membrane; immersion precipitation method |
