| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Drug Delivery System Using In Situ-Forming Gel For Cancer Therapy |
| 초록 |
Injectable in situ-forming gels have received considerable attention as localized drug-delivery systems. Here, we examined a poly(ethylene glycol)-b-poly caprolactone (MPEG-PCL) diblock copolymer gel as an injectable drug depot for paclitaxel (Ptx). During the last decade, injectable in situ-forming gels have attracted considerable attention as polymeric drug carriers. Among the advantages of such gels are their ability to conform to any shape at a specific site, and the fact that they can be introduced using minimally invasive non-surgical procedures. The overall aim of the current study was to develop a simple and generally applicable intratumoral injection strategy for systemic chemotherapy using Ptx. In conclusion, our data show that intratumoral injection of Ptx-loaded MPEG-PCL diblock copolymer yielded an in situ-forming gel that exhibited controlled Ptx-release profile, and that was effective in treating localized solid tumors. |
| 저자 |
김재일1, 이상효1, 손진수1, 강휘주1, 권두연2, 이해방1, 민병현1, 김재호1, 김문석1
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| 소속 |
1아주대, 2부경대 |
| 키워드 |
injectable in situ gel; tumors; paclitaxel; drug deilvery system
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| E-Mail |
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