| 학회 |
한국고분자학회 |
| 학술대회 |
2002년 봄 (04/12 ~ 04/13, 서울대학교) |
| 권호 |
27권 1호, p.274 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis of Polyanhydride Copolymer and Its In Vitro Biodegradability. |
| 초록 |
Poly(carboxyphenoxypropane : sebaic) anhydride copolymer was synthesized as biodegradable aliphatic-aromatic polyanhydride by melt-polycondensation. SA prepolymer and CPP prepolymer were prepared by reacting SA and CPP with excess acetic anhydride. Molecular weight, thermal property. and crystallinity of poly(CPP:SA) were characterized by GPC, DSC, and XRD respectively. Polymers of higher molecular weights were synthesized with increase of polymerization temperature and time but, above the optimized condition , the molecular weights were decresed due to formation of cyclic macremers. Composition of copolymers identified by 1H-NMR analysis were well matched to prepolymer feed ratio. Crystallinity of copolymers decreased with increase of CPP fraction in copolymer composition. In vitro biodegradability of poly(CPP:SA) impregnated in PBS, 37℃ was evaluated by determining molecular weight change, mass loss, and release of monomers during degradation test period.
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| 저자 |
강희정1, 안태군2, 이진수3, 김영은*4, 성하수**, 강길선, 이종문*, 이정식***, 이해방**
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| 소속 |
1전북대, 2*전북대, 3**한국화학(연), 4***삼천당제약 중앙(연) |
| 키워드 |
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| E-Mail |
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