화학공학소재연구정보센터
학회 한국공업화학회
학술대회 2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU))
권호 22권 2호
발표분야 신진과학자포럼
제목 Advanced technologies for molecular profiling of tumor-derived extracellular vesicles
초록 A growing number of studies show that extracellular vesicles (EVs) may function as reliable surrogates of parental cells. With their abundance and structural stability, these vesicles can better reflect overall tumor burden, overcoming limitations of tumor heterogeneity and sampling bias. Rapid and accurate analysis of EVs is, however, hampered by practical challenges: 1) lengthy isolation procedures resulting low yield and poor purity, 2) lack of ultrasensitive bioassays and disease-specific biomarkers. Standardized bioassays, optimized for these nano-sized vesicles, have yet to be developed to fully evaluate EVs’ clinical potential. In this presentation, current efforts to develop advanced sensing systems for high-throughput analysis of EVs will be discussed. In particular, the clinical reliability of a nano-plasmonic sensor-based bioassay facilitating diagnosis of pancreatic malignancy and new approaches to develop plastic-based devices for point-of-care testing will be introduced.
저자 홍선기
소속 대구경북과학기술원 (DGIST)
키워드 Extraocular vesicle; Nano-plasmonic sensor; Point-of-care testing; Bioassay
E-Mail seonkihong@dgist.ac.kr