| 초록 |
Biodegradable polymers and hydrogels have been increasingly applied in a variety of biomedical applications, including current drug delivery system and tissue engineering field. α,β-Poly(N-2-hydroxyethyl-DL-aspartamide), PHEA, is one of poly(amino acids) with hydroxyethyl pendants, which is known to be biodegradable and potentially biocompatible. Therefore, the utilization and various chemical modifications of PHEA have been attempted for useful biomedical applications. In this work, chemical gels based on PHEA were prepared by crosslinking with glutaraldehyde and diisocyanate compound, respectively. Also, PHEA composite hydrogel with chitosan, a natural carbohydrate polymer, was prepared by co-crosslinking with glutaraldehyde in water. The preparation of gels and their swelling behavior, depending on the different medium and pH, the morphology by SEM, and cytotoxicity test are investigated. In addition, some results on the hydrolytic degradation and the release behavior of a model drug are included. |
