| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.80 |
| 발표분야 | 신진 연구자 특별심포지움 |
| 제목 | Electrospun Polymeric Nanofiber: Its Applications |
| 초록 | Electrospinning is used to fabricate very fine polymer fibers (50-500 nm in diameter) by applying a high electric field to the polymer solution or melt. The underlying physics of this technique relies on the fact that the applied electrical force at the polymer droplet surface overcomes the surface tension force, thereby a charged jet is ejected. As the solvent evaporates, the charge density increases on the fibers, resulting in an unstable jet, which stretches the fibers more than one million fold. The final product consists of randomly interconnected webs of sub-micron size fibers. Electrospun non-woven scaffolds based on a three-component blend of PLGA, PLA-b-PEG-b-PLA triblock copolymer and DNA were employed for biomedical applications, such as storage and delivery of drugs, genes and cells as well as prevention of post-surgical adhesion. Not only biodegradation rate and hydrophilicity but also the morphology of the electrospun scaffolds were finely tuned with the material composition and processing parameter. Successful incorporation and sustained release of a hydrophilic antibiotic drug (cefoxitin sodium) or DNA from electrospun poly(lactide-co-glycolide) (PLGA) based nanofibrous scaffolds without the loss of structure or bioactivity was demonstrated. In particular, medicated PLGA-based electrospun scaffolds containing antibiotic drugs were shown to hold a future potential to prevent post-surgical adhesions and infections. In the area of ultra-filtration, electrospun nanofibrous membrane could replace traditional foam or hollow fiber type filter for high flux and low fouling bilge water filtration. Electrospun poly(acrylonitrile)(PAN) had outstanding high flux filtration behavior because of its extremely large inter-connected void volume and surface area. The average fiber diameter of electrospun PAN nanofibers was about 400 nm, and a composite filter (polyester micro-filter/electrospun PAN bi-layer filter) was mechanically stable at high pressure (ca. 120 psi) and showed high flux filtration behavior in dead-end flow test (medium : lab. water). The flux of composite filter was 13-16 times larger than that of the commercial high-flux ultra-filtration (UF) filter membrane. References (1) J. Doshi, D. H. Reneker, J. Electrost. 35, 151 (1995). (2) H. Fong, I. Chun, D. H. Reneker, Polymer, 40, 4585 (1999). (3) Y. M. Shin, M. M. Hohman, M. P. Brenner, G. C. Rutledge, Polymer, 42, 9955 (2001). (4) X. Zong, K. Kim, D. Fang, S. Ran, B. S. Hsiao, B. Chu, Polymer, 43, 4403 (2002). (5) K. Kim, C. Chang, Y. K. Luu, D. Fang, B. S. Hsiao, B. Chu, M. Hadjiargyrou, J. Control. Release, 98, 47 (2004). (6) K. Kim, M. Yu, X. Zong, J. Chiu, D. Fang, Y. Seo, B. S. Hsiao, B. Chu, M. Hadjiargyrou, Biomaterials, 24, 4977 (2003). (7) K. S. Kim, S. Chung, I. J. Chin, J.S. Yoon, J. Appl. Polym. Sci. 72, 341 (1999). (8) P. Gibson, H.Schreuder-Gibson, D. Rivin, Colloids and Surfaces A 187-188, 469 (2001). |
| 저자 | 김광석1, Benjamin S. Hsiao2, Benjamin Chu3, Michael Hadjiargyrou2 |
| 소속 | 1인하대, 2Dept of Chemistry, 3State Univ. of New York at Stony Brook |
| 키워드 | Electrospinning; Nanofibrous membrane; PLA; PLGA; Scaffold |
