| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis and Self-assembling Properties of Poly(ethylene glycol)/poly(ε-caprolactone) AB2 Miktoarm Copolymers for Anticancer Drug Delivery |
| 초록 |
Amphiphilic AB2 miktoarm copolymers that mimic structural characteristics of phospholipid show a high potential for forming nanostructures and application as an efficient drug carrier system. In this study, a series of new amphiphilic AB2 miktoarm copolymers consisting of hydrophilic PEG block and hydrophobic PCL block were synthesized. The chemical compositions of PEG-PCL2 miktoarm copolymers were confirmed by 1H-NMR, GPC, and FT-IR measurements. The PEG-PCL2 miktoarm copolymers with relatively short PCL blocks readily formed spherical micelles when they self-assembled in aqueous solution. However, the worm-like micellar structure was observed when the length of PCL blocks increased. Dxorubicin (DOX) was efficiently loaded into PEG-PCL2 miktoarm nanocarriers. In vitro release profiles of Dox-loaded self-assembled nanocarriers showed sustained release patterns. PEG-PCL2 miktoarm nanocarriers exhibited enhanced cellular uptake into cells compared to Dox. |
| 저자 |
윤권혁1, 이립1, 강한창2, 배유한3, 허강무1
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| 소속 |
1충남대, 2가톨릭대, 3유타대 |
| 키워드 |
miktoarm copolymer; self-assembled nanocarriers; PEG; PCL; doxorubicin
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| E-Mail |
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