| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 가을 (10/30 ~ 11/01, 대전컨벤션센터) |
| 권호 |
17권 2호 |
| 발표분야 |
포스터-정밀화학 |
| 제목 |
Self-assembled nanoparticles based on hydrophobic modified water-soluble chitosan as a drug delivery carrier |
| 초록 |
The objective of the present study was to develop a new drug carrier consisting of water-soluble chitosan (SC) with hydrophobic moiety. We found that hydrophobic moiety modified soluble chitosan (HSC) can be loaded the anticancer drug which has poor solubility in water. The particles formed the self-aggregates in an aqueous solution by hydrophobic interaction between HSC and anticancer drug. Characterization of drug-loaded HSC was analysed by FT-IR, 1H-NMR, DLS and HPLC studies. These results suggest that HSC can be applied as a carrier of drug delivery. This research was supported by basic Science Research Program through the National Research Foundation of Korea (NRF) funded the Ministry of Education. Science and Technology (NRF-2011-0012039). |
| 저자 |
정경원, 손동희, 박순정, 변지예, 박성철, 최창용, 나재운, 장미경
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| 소속 |
순천대 |
| 키워드 |
hydrophobic; soluble chitosan; anticancer drug
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| E-Mail |
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