| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 | 28권 2호, p.176 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Effect of glycolide and lactide monomers on the release profiles of BCNU from BCNU-loaded PLGA wafer |
| 초록 | 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has been used as a chemotherapeutic agent for brain tumor. Small sized BCNU-loaded PLGA wafer has been developed to insert into tumor bearing rat model for in vivo test. Accordig to a wafer size, release rate was affected and the small wafer must represent the same release profiles as the wafer which is used for clinical trial. Poly(lactic-co-glycolic acid) (PLGA) is biodegradable polymer composed of lactide and glycolide monomers which are also biodegradable monomers. In our present study, the effect of glycolide and lactide monomers on the release profiles of BCNU from BCNU-loaded PLGA wafer, repectively was assayed by high performance liquid chromatography (HPLC) at 248㎚. Also, change of media pH was measured and surface and cross section of wafer morphology was observed by scanning electron microscopy (SEM) during release period. Release rate was increased with increasing amount of glycolide and lactide monomers, respectively due to increasing porosity and channels in matrix. So the release profiles could be controlled and the formulation showing near zero-order release was obtained. Acknowledgment: This work was supported by KMOCIE |
| 저자 | 채강수1, 이진수1, 강복기1, 정제교2, 김문석3, 조선행3, 강길선1, 이해방3 |
| 소속 | 1전북대, 2삼천당제약 중앙(연), 3한국화학(연) |
| 키워드 | Poly(lactic-co-glycolic acid) (PLGA); BCNU; lactide and glycolide monomer; wafer |
