| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 | 28권 2호, p.180 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Characterization of poly(D.L-lactide-co-glycolide) degradation behavior by high performance liquid chromatography method |
| 초록 | The aim of this study was to detect the amount of monomers (i.e. lactic/glycolic acid) degraded from poly(D.L-lactide-co-glycolide) (PLGA) by development a simple HPLC method and to determine the pH of media, which can influence on degradation of PLGA. Analysis of in vitro degradation behavior of Resomer RG 502 H and RG 503 H were performed in various media conditions (pH 3.0, 5.0, 7.0, and 9.0 of PBS and distilled water (approx. pH 5.8)). Effect of additives on PLGA degradation was also investigated in pH 7.0 of PBS. Lactic acid (LA) and glycolic acid (GA) were easily detected by a simple HPLC method (retention time; 10.2 min and 6.5 min, respectively). The result showed that GA was detected larger amount than that of LA considering the initial sample weight of polymers, according to the relatively higher hydrophilic property. In the lower pH of media conditions, the PLGA was faster degraded generally. The presence of various additives, moreover, affected decrease of pH and slight acceleration of LA and GA detection. Acknowledgment : This work was supported by KMOHW and KOSEF (R01-2001-00431) |
| 저자 | 유제영1, 김종민1, 서광수1, 김문석2, 조선행2, 강길선2, 이해방2 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | PLGA; Glycollic acid; Lactic acid; HPLC |
