| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Sustained Release of BDNF using Temperature Sensitive MPEG-PCL Hydrogels |
| 초록 |
Methoxy poly(ethyleneglycol) (MPEG)-b-poly(ε-caprolactone) (PCL) diblock copolymer was synthesized by ring-opening of ε-caprolactone (ε-CL). The temperature sensitive behavior of the prepared MPEG-PCL diblock copolymer was examined in aqueous. The MPEG-PCL diblock copolymer was dissolved in water at 80 ℃. The formed sol became gel at 31 ℃ as the temperature increased. On further increase of the temperature, the gel changed to sol at 52 ℃. This indicates the diblock copolymer solutions at room temperature can form gel at body temperature. Brain derived neurotrophic factor (BDNF) loaded MPEG-PCL diblock copolymer solution was prepared to observe the release behavior of growth factor by ELISA. The release profile of BDNF in MPEG-PCL gel showed the sustained release for 20 days. So we confirmed that MPEG-PCL diblock copolymer solutions is useful as BDNF carriers. Acknowledgement : This study was supported by KMOHW (grant no A050082) |
| 저자 |
조미희1, 김선경1, 현훈1, 신유나1, 강길선2, 이봉3, 이해방1, 김문석1
|
| 소속 |
1한국화학(연), 2전북대, 3부경대 |
| 키워드 |
하이드로겔; BDNF
|
| E-Mail |
|
