| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Transdermal drug Delivery with Microneedle System |
| 초록 | The success of transdermal drug delivery has been severely limited by the inability of most drugs to enter the skin at therapeutically useful rates. Recently, the use of micron-scale needles in increasing skin permeability has been proposed and shown to dramatically increase transdermal delivery, especially for macromolecules.1,2 The present study was designed to develop the microneedle type transdermal drug delivery system using OVA, Insulin as model protein drug. (Figure 1). The in vitro study of SD rat's skin permeability for drug was carried out at PBS, 37 ℃ for 12 hour with a modified Franz's diffusion cell after the skin treatment by microneedle system. The drug release was determined by fluorescence spectrophotometer and compared at molecular weights of each drug. The size of hole which was pierced to the skin was 35 μm by microneedle system. The microneedle system pierced holes which are 35 μm in the skin. Microneedle-treated skin indicated higher drug permeability than those of control. And the drug permeability increased as the treatment time increased. The drug permeability was differed, because of drug molecular weight. Figure 1. Picture of microneedle system used for transdermal drug delivery. Acknowledgment : This work was supported by KMOCIE References 1. M. R. Prausnitz, Adv. Drug Deliv. Rev., 56, 581-587 (2004) 2. J. A. Matriano, M. Cormier, J. Johnson, W. A. Young, M. Buttery, K. Nyam and P. E. Daddona, Pharm. Res., 19, 63-70 (2002) |
| 저자 | 이창래1, 장우영1, 엄성용2, 이한구2, 이종문1, 이해방3, 강길선1 |
| 소속 | 1전북대, 2대신제약, 3한국화학(연) |
| 키워드 | microneedle; transdermal; OVA; Insulin |
