| 학회 | 한국화학공학회 |
| 학술대회 | 2007년 가을 (10/26 ~ 10/27, 한국과학기술원) |
| 권호 | 13권 2호, p.2608 |
| 발표분야 | 제4회 약물전달(DDS) 기술 심포지엄 |
| 제목 | Comparison of Anesthetic Effects of Lidocaine Hydrochloride Gel using Low and High Frequency Ultrasound |
| 초록 | Low-frequency ultrasound has a significant effect on the transdermal permeation of high molecular weight drugs. However, the rate of permeation in pulsed mode is quite low necessitating considerable time to apply the ultrasound. Normaly 1MHz of ultrasound was uswd clinically. 0.5 ㎒ ultrasound, which is a relatively higher frequency in the low-frequency range, can be applied in high intensity in continuous mode. 1MHz and 0.5㎒ ultrasound and a transducer were used to administer an anesthetic drug transdermally on healthy volunteers and transdermal effects in vitro. And the anesthetic effects were examined. The parameters of transdermal factors were evaluated and compared. In surface anesthesia, the phonophoresis group showed a significantly higher pain threshold than the other groups but there was no significant difference between the phonophoresis groups according to the ultrasound frequency. In conduction anesthesia, the 0.5 ㎒ phonophoresis group showed a significant change in their pain threshold and amplitude of sensory nerve action potential (SNAP) compared with the other groups. |
| 저자 | 김영일1, 김태열2 |
| 소속 | 1건양대, 2동신대 |
| 키워드 | Lidocaine; Ultrasound; TDDS |
| VOD | VOD 보기 |
| 원문파일 | 초록 보기 |
