| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Thermosensitive META-Pluronic-Glycolide-Heparin Hydrogel for proliferation and differentiation of adipose-derived stem cells |
| 초록 |
Pluronic is nontoxic poly(ethylene oxide)-(polypropylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers that form a thermoreversible gel. It has found a wide variety of applications in tissue engineering and drug delivery. In this work, a functional Pluronic (F127) derivative, such as 4-methacryloxyethyl trimellitic anhydride(META), glycolide, and heparin-grafted Pluronic (F127-G5-META-Heparin) was synthesized and then the derivative was subjected to binding to transforming growth factor(TGF-β). The effects of the TGF-β-incorporated hydrogel tasted were in the chondrogenic differentiation, of adipose-derived stem cell (ASC). The cell-encapsulated hydrogels were cultured for specific times and evaluated for cell number, viability, cartilage-specific ECM synthesis, and gene expression levels of collagen type I and II. This Pluronic-based hydrogel system is expected to be useful as an injectable hydrogel for tissue regeneration. |
| 저자 |
정홍희1, 박귀덕1, 김병수2, 박기동3, 안광덕1, 한동근1
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| 소속 |
1한국과학기술(연), 2한양대, 3아주대 |
| 키워드 |
Tissue engineering; Pluronic; Hydrogels; Heaprin; Adipose-derived stem cells
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| E-Mail |
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