| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.652 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation of Hyperbranched Surface by Photopolymerization |
| 초록 | Various surface structures have been developed for the study of biocompatibility in biomedical applications and precise architecture of surface graft chain may be needed for more biocompatible surface structure. As based on this concept, the multigeneration hyperbranched surfaces were prepared for the study of blood/cell compatibility as the branching generation degree. These hyperbranched surfaces were made up to three generations by simple photopolymerization using iniferter, the benzyl N,N-Diethyldithiocarbamate (DC) group. The principle for obtaining multigeneration hyperbranched surface is based on a sequential reaction of iniferter copolymerization with vinylbenzyl chloride (VBC) and subsequent dithiocarbamylation of the VBC units in copolymer. At first, the synthesized photoreactive copolymer, poly(styrene-co-vinylbenzyl N,N-Diethyldithio carbamate) was coated on the PET film. And then stem chain (first generation) surface was prepared with poly(ethylene glycol) methacrylate (PEGMA) and VBC monomers by UV photopolymerization and VBC units in stem chain were dithiocarbamated. Subsequently, a branched chain (second generation) was photopolymerized with PEGMA and VBC monomers on the multiply derivatized DC units in the stem chain. The twig chain (third generation) was prepared by the same method (sequential dithiocarbamylation/photopolymerization) on the branched chain. The hyperbranched surfaces were characterized by XPS and contact angle measurement. And the biological activity of the hyperbranched surface was estimated with protein adsorption and platelet adhesion test. The cell study on the hyperbranched surfaces is under investigation. It is expected that these hyperbranched surfaces can be applied as a polymeric substrate for the control of cellular responses and for improving biocompatibility. |
| 저자 | 김태은1, 배진우1, 이준우2, 박기동1 |
| 소속 | 1아주대, 2한국과학기술정보(연) |
| 키워드 | hyperbranched surface; biocompatibility; photopolymerization |
