| 초록 |
In this study, the poly(ε-caprolactone) (PCL) microcapsules containing chemically treated SiO2 and nifedipine were prepared in the release behaviors of microcapsules. The PCL microcapsules containing drugs were confirmed using FT-IR. The inclusion of nifedipine into PCL microcapsules was determined in the presence of drug's specific peak, i.e., C=O stretch vibration at 1682 cm-1. And the morphologies of PCL microcapsules were observed with image analyzer and scanning electron microscope (SEM). As a result, the average particle size of PCL microcapsules was decreased with the increase of the stirring rate. Also, the drug's release behaviors of PCL microcapsules were obtained with UV/vis spectra. It was found that in the case of using basic treated SiO2 the release time of drug was increased while the adsorption capacity of drug on SiO2 was decreased due to the decreased specific surface area of SiO2. |
