| 초록 |
Heparin-based nanoparticle, self-assembled from heparin-poly(β-benzyl-L-aspartate) (HP) copolymer, were prepared for doxorubicin (DOX) delivery. Folate-PEG was chemically conjugated to heparin backbone to achieve folate receptor targeted delivery. DOX was effectively incorporated into HP and FPHP nanoparticles at a high loading content. The DOX-loaded nanoparticles had an average diameter of 86-207 nm, a negatively charged surface, and a pH-dependent drug release pattern. Furthermore, DOX-loaded FPHP nanoparticles demonstrated marked extent of cellular uptake and cytotoxicity than DOX-loaded HP nanoparticles against KB cell with over-expressing folate receptors on the surface. These findings suggest that DOX-loaded FPHP nanoparticles have the potential as an effective delivery system for clinical chemotherapy. |
